{"id":33,"date":"2024-04-24T17:21:16","date_gmt":"2024-04-24T08:21:16","guid":{"rendered":"https:\/\/nagasaki-u-immunology.com\/?page_id=33"},"modified":"2026-04-20T17:06:52","modified_gmt":"2026-04-20T08:06:52","slug":"publication","status":"publish","type":"page","link":"https:\/\/nagasaki-u-immunology.com\/?page_id=33","title":{"rendered":"\u696d\u7e3e"},"content":{"rendered":"\n

2026\u5e74<\/h3>\n\n\n\n

An observational study to test the potency of GLP-grade phenol-free lyophilised leishmanin antigen formulation<\/a><\/p>\n\n\n\n

Thalia Pacheco-Fernandez\u2020,\u00a0Laura Klenow\u2020,\u00a0Shin-Ichi Inoue<\/strong>\u2020,\u00a0Kamaleshwar P Singh\u2020,\u00a0Farzaneh Valanezhad\u2020,\u00a0Hannah Markle,\u00a0Nazli Azodi,\u00a0Meghan Brino,\u00a0Shara Bakytbek,\u00a0Caroline Hobson,\u00a0Ishaan Jain,\u00a0Pratik Talgaonkar,\u00a0Shalu Shukla,\u00a0Pawan Kardile,\u00a0Swarnendu Kaviraj,\u00a0Larissa O Silva,\u00a0Pedro B Borba,\u00a0Marina Santana,\u00a0Taylla Costa,\u00a0Greg Matlashewski,\u00a0Lucas P Carvalho,\u00a0Edgar M Carvalho,\u00a0Camila I de Oliveira,\u00a0Abhay R Satoskar*,\u00a0Sanjay Singh*,\u00a0Shinjiro Hamano*,\u00a0Sreenivas Gannavaram*,\u00a0Hira L Nakhasi*<\/p>\n\n\n\n

EBioMedicine<\/em><\/strong>,<\/a><\/a> 2026 Apr 16:106246. doi: 10.1016\/j.ebiom.2026.106246..<\/p>\n\n\n\n

\u2020These authors contributed equally. *Corresponding authors.<\/p>\n\n\n\n

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2025\u5e74<\/h3>\n\n\n\n

Performance evaluation of the automated haematology analyzer XN-31 for malaria diagnosis in Plasmodium vivax-dominant regions of Thailand.<\/p>\n\n\n\n

Kawaguchi M, Komaki-Yasuda K, Nakatsu M, Kerdsakundee N, Hamana M, Tougan T<\/strong>, Kamei M, Konishi A, Krudsood S, Kano S<\/p>\n\n\n\n

Malar J.<\/strong> 2025 Dec 29;25(1):67. doi: 10.1186\/s12936-025-05763-2. PMID: 41466282; PMCID: PMC12857124.<\/p>\n\n\n\n

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Protective Effects of Maternal Administration of a Standardized Extract of Cultured Lentinula edodes Mycelia against Radiation-Induced Fetal Morphological Abnormalities.<\/p>\n\n\n\n

Adachi S\u2020<\/strong><\/a>, Tougan T<\/strong>\u2020<\/strong><\/a>, Kimura C, Takanari J, Wakame K, Aoshi T,<\/strong> Nomura T.<\/p>\n\n\n\n

Biol Pharm Bull.<\/strong> 2025;48(11):1810-1812. doi: 10.1248\/bpb.b25-00466. PMID: 41320310.<\/p>\n\n\n\n

\u2020<\/strong><\/a>These authors contributed equally: Shigeki Adachi, Takahiro Tougan<\/p>\n\n\n\n

Oral Administration of 5-Aminolevulinic Acid Does Not Ameliorate Autoimmune Diabetes in NOD Mice<\/a><\/p>\n\n\n\n

Shinpei Nishikido, Satoru Akazawa, Tetsuro Niri, Shin-Ichi Inoue<\/strong>, Katsuya Matsuda, Taiki Aoshi<\/strong>, Masahiro Nakashima, Ai Haraguchi, Ichiro Horie, Masakazu Kobayashi \u2026<\/p>\n\n\n\n

Diabetology<\/strong> 6(7) 62-62 2025\u5e747\u67081\u65e5<\/p>\n\n\n\n

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Continuous Ingestion of a Standardized Extract of Cultured Lentinula edodes <\/em>Mycelia Suppresses Spontaneous Carcinogenesis in a Murine Model.<\/a><\/p>\n\n\n\n

Adachi S, Tougan T<\/strong>, Ryo H, Takanari J, Wakame K, Aoshi T<\/strong>, Nomura T.<\/p>\n\n\n\n

Biol Pharm Bull.<\/em><\/strong>, 48(5): 687-693. doi: 10.1248\/bpb.b24-00641. PMID: 40414724.<\/p>\n\n\n\n

\u2020<\/strong><\/a>These authors contributed equally: Shigeki Adachi, Takahiro Tougan<\/p>\n\n\n\n

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Essential role of interferon-regulatory factor 4 in regulating diabetogenic CD4+<\/sup> T and innate immune cells in autoimmune diabetes in NOD mice.<\/a>
Tetsuro Niri, Shin-Ichi Inoue<\/strong>, Satoru Akazawa, Shinpei Nishikido, Masaki Miwa, Masakazu Kobayashi, Katsuyuki Yui, Minoru Okita, Atsushi Kawakami, Norio Abiru.<\/p>\n\n\n\n

Clinical and Experimental Immunology<\/em><\/strong>, 219(1): uxae093. doi: 10.1093\/cei\/uxae093.<\/p>\n\n\n\n

2024\u5e74<\/h3>\n\n\n\n

Regulation of memory CD4+<\/sup> T-cell generation by intrinsic and extrinsic IL-27 signaling during malaria infection.<\/a><\/p>\n\n\n\n

Tsogtsaikhan S, Inoue SI<\/strong>, Bayarsaikhan G, Macalinao ML, Kimura D, Miyakoda M, Yamamoto M, Hara H, Yoshida H, Yui K.<\/p>\n\n\n\n

Int Immunol.<\/em><\/strong>, 36(12):629-640. doi: 10.1093\/intimm\/dxae039.<\/p>\n\n\n\n

\u03b3\u03b4 T cell-mediated activation of cDC1 orchestrates CD4+<\/sup> Th1 cell priming in malaria.<\/a><\/p>\n\n\n\n

Yarob Ibraheem<\/strong>, Ganchimeg Bayarsaikhan, Maria Lourdes Macalinao, Kazumi Kimura<\/strong>, Katsuyuki Yui, Taiki Aoshi<\/strong>, Shin-Ichi Inoue<\/strong>.
Frontiers in Immunology<\/em><\/strong>, doi: 10.3389\/fimmu.2024.1426316.<\/p>\n\n\n\n

Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer.<\/a><\/p>\n\n\n\n

Hirai T, Naito Y, Koyama S, Nakanishi Y, Masuhiro K, Izumi M, Kuge T, Naito M, Mizuno Y, Yamaguchi Y, Kang S, Yaga M, Futami Y, Nojima S, Nishide M, Morita T, Kato Y, Tsuda T, Takemoto N, Kinugasa-Katayama Y, Aoshi T<\/strong>, Villa JK, Yamashita K, Enokida T, Hoshi Y, Matsuura K, Tahara M, Takamatsu H, Takeda Y, Inohara H, Kumanogoh A.<\/p>\n\n\n\n

JCI Insight.<\/em><\/strong>, 9(3): e166349. doi: 10.1172\/jci.insight.166349.<\/p>\n\n\n\n

2023<\/strong>\u5e74<\/strong><\/h3>\n\n\n\n

Maria Lourdes Macalinao, Shin-Ichi Inoue, Sanjaadorj Tsogtsaikhan, Hirotaka Matsumoto, Ganchimeg Bayarsaikhan, Jiun-Yu Jian, Kazumi Kimura, Yoshiaki Yasumizu, Hiroki Yoshida, Julius Hafalla, Daisuke Kimura, Katsuyuki Yui.
IL-27 produced during acute malaria infection regulates Plasmodium<\/em>-specific memory CD4+ T cells.
EMBO Mol Med<\/strong>, 15: e17713, 2023

Hiroko Asahi, Mamoru Niikura, Shin-Ichi Inoue, Fujiro Sendo, Fumie Kobayashi, Akira Wada.
Dihydroartemisinin Disrupts Zinc Homeostasisin Plasmodium falciparum<\/em> To Potentiate Its Antimalarial Action via Pyknosis.
ACS Infect Dis<\/strong>, 9(7):1303-1309, 2023

Ganchimeg Bayarsaikhan, Yarob Ibraheem, Shin-Ichi Inoue.
\u03b3\u03b4 T-cell-mediated immune responses to malaria.
Microbiol Immunol<\/strong>, 67(5):239-247, 2023

Yarob Ibraheem, Ganchimeg Bayarsaikhan, Shin-Ichi Inoue.
Host immunity to Plasmodium infection: Contribution of Plasmodium berghei<\/em> to our understanding of T cell-related immune response to blood-stage malaria.
Parasitol Int<\/strong>, 92:102646, 2023<\/p>\n\n\n\n

2022\u5e74<\/h3>\n\n\n\n

Arshad Mahmood, Keisuke Yaku, Keisuke Hikosaka, Maryam Gulshan, Shin-ichi Inoue, Fumie Kobayashi, Takashi Nakagawa.
Nmnat3 deficiency in hemolytic anemia exacerbates malaria infection.
Biochem Biophys Res Commun<\/strong>, 637:58-65, 2022

Mbaya Ntita, Shin-Ichi Inoue, Jiun-Yu Jian, Ganchimeg Bayarsaikhan, Kazumi Kimura, Daisuke Kimura, Mana Miyakoda, Eriko Nozaki, Takuya Sakurai, Daniel Fernandez-Ruiz, William R. Heath, Katsuyuki Yui.
Type I interferon production elicits differential CD4+ T-cell responses in mice infected with Plasmodium berghei <\/em>ANKA and P. chabaudi<\/em>.
Int Immunol,<\/strong> 34(1), 21-33, 2022<\/p>\n\n\n\n

2021\u5e74<\/h3>\n\n\n\n

Hiroo Wada, Masuo Nakamura, Shin\u2011Ichi Inoue, Akihiko Kudo, Tomoko Hanawa, Yoichiro Iwakura, Fumie Kobayashi, Hiroshi Kamma, Shigeru Kamiya, Kazuhiro Ito, Peter J. Barnes, Hajime Takizawa.
Dual interleukin\u201117A\/F deficiency protects against acute and chronic response to cigarette smoke exposure in mice.
Sci Rep<\/strong>, 11(1):11508, 2021

Jiun-Yu Jian, Shin-Ichi Inoue, Ganchimeg Bayarsaikhan, Mana Miyakoda, Daisuke Kimura, Kazumi Kimura, Eriko Nozaki, Takuya Sakurai, Daniel Fernandez-Ruiz, William R. Heath, Katsuyuki Yui.
CD49d marks Th1 and Tfh-like antigen-specific CD4+ T cells during Plasmodium chabaudi<\/em> infection.
Int Immunol<\/strong>, 33(8), 409-422, 2021

Katsuyuki Yui, Shin-Ichi Inoue.
Host-pathogen interaction in the tissue environment during Plasmodium<\/em> blood-stage infection.
Parasite Immunol, 43(2):e12763, 2021<\/p>\n\n\n\n

2020\u5e74<\/h3>\n\n\n\n

Mamoru Niikura, Toshiyuki Fukutomi, Kana Fukui, Shin-Ichi Inoue, Hiroko Asahi, Fumie Kobayashi.
G-strand binding protein 2 is involved in asexual and sexual development of Plasmodium berghei<\/em>.
Parasitol Int<\/strong>, 76:102059, 2020

Odsuren Sukhbaatar, Daisuke Kimura, Mana Miyakoda, Sayuri Nakamae, Kazumi Kimura, Hiromitsu Hara, Hiroki Yoshida, Shin-Ichi Inoue, Katsuyuki Yui.
Activation and IL-10 production of specific CD4+ T cells are regulated by IL27 during chronic infection with Plasmodium chabaudi<\/em>.
Parasitol Int<\/strong>, 74:101994, 2020<\/p>\n\n\n\n

2019\u5e74<\/h3>\n\n\n\n

S Nakamae, D Kimura, M Miyakoda, O Skhbaatar, S Inoue, K Yui.
Role of IL-10 in inhibiting protective immune responses against infection with heterologous Plasmodium<\/em> parasites.
Parasitol Int<\/strong>, 70: 5-15, 2019.<\/p>\n\n\n\n

2018\u5e74<\/h3>\n\n\n\n

Shin-Ichi Inoue, Mamoru Niikura, Hiroko Asahi, Yasushi Kawakami, Fumie Kobayashi.
\u03b3\u03b4 T cells modulate humoral immunity against Plasmodium berghei<\/em> infection.
Immunology<\/strong>, 155(4)519-532, 2018<\/p>\n